The antimicrobial resistance rate of Methicillin-Resistant Staphylococcus aureus in the country remained above 50% since 2010. This study aimed to characterize the circulating clones of MRSA in the Philippines. A total of 116 S. aureus isolates from the Antimicrobial Resistance Surveillance Program (2013-2014) were subjected to whole genome sequencing.  The MRSA population in the Philippines was composed of a limited number of genetic clones, including several international epidemic clones. Resistance to sulfamethoxazole/trimethoprim of the isolates revealed independent acquisition mechanisms. he concordance between phenotypic and genotypic resistance was 99.68% overall for 8 antibiotics in 7 classes.

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